Product Description
Meglumine, also known as N-Methyl-D-glucamine or N-Methylglucamine, is an amino sugar derivative of sorbitol with the chemical formula C₇H₁₇NO₅ and CAS number 6284-40-8. Its molecular structure contains several hydroxyl groups and a secondary amino group, giving the compound a strongly hydrophilic character and acid–base functionality.
In pharmaceutical chemistry, Meglumine is used as a counterion, formulation excipient, and pH-adjusting component in selected applications. It can be combined with suitable acidic active ingredients to form meglumine salts, potentially changing properties such as aqueous solubility and formulation behavior. Its role in iodinated contrast-media salts is another established area of use.
Meglumine is generally supplied as a white to off-white crystalline powder or solid and is readily soluble in water. These characteristics make it relevant to aqueous formulation development, pharmaceutical ingredient processing, and chemical research. Actual performance depends on the compound being formulated, solution conditions, the selected grade, and the requirements of the final application.
For buyers evaluating Meglumine CAS 6284-40-8, the appropriate grade should be selected according to the intended use, assay requirements, impurity profile, and applicable quality standards.
Meglumine Chemical Properties
| Property | Details |
|---|---|
| Product Name | Meglumine |
| CAS Number | 6284-40-8 |
| Synonyms | N-Methyl-D-glucamine; N-Methylglucamine |
| Molecular Formula | C₇H₁₇NO₅ |
| Molecular Weight | 195.21 g/mol |
| Chemical Class | Amino sugar; polyhydroxylated amine |
| Appearance | White to off-white crystalline powder or solid |
| Melting Point | Approximately 129–131.5°C |
| Water Solubility | Freely soluble in water; reported values vary with test conditions |
| pKa | Approximately 9.4–9.6, depending on measurement conditions |
| Aqueous pH | Approximately 11 for a 10 g/L aqueous solution at 20°C, as reported in reference data |
| Main Functional Groups | Hydroxyl groups and a secondary amino group |
| Storage | Keep tightly closed and protected from moisture; follow the product-specific SDS and supplier instructions |
Property note: Meglumine can absorb moisture from the surrounding air, so exposure during sampling and handling may affect the material's condition and test results. The pKa and aqueous pH values describe different properties and should not be treated as interchangeable. For purchasing specifications, use the current product-specific TDS, SDS, and COA to confirm the actual grade, assay, water content, and storage conditions.
Product Applications
1. Pharmaceutical Formulation Development
Meglumine is used as a formulation component in selected pharmaceutical systems. Its suitability depends on compatibility with the active ingredient, the target pH, and the intended dosage form.
2. Salt Formation and Solubility Studies
As a basic amino sugar, Meglumine can be used to prepare salts with suitable acidic compounds. Researchers may evaluate the resulting salt's solubility, stability, and processing behavior during formulation development.
3. Iodinated Contrast Media
Meglumine is used in the preparation of certain iodinated contrast-media salts, including diatrizoate meglumine. This application makes it relevant to specialized pharmaceutical and diagnostic-agent manufacturing.
4. pH Adjustment and Aqueous Formulations
The amino group contributes basicity, allowing Meglumine to be considered in selected pH-adjustment and aqueous formulation systems. The required concentration and compatibility should be established through formulation testing.
5. Pharmaceutical and Chemical Research
Meglumine may be used in laboratory studies involving salt formation, excipient screening, analytical evaluation, and the development of specialized chemical formulations.
FAQ
Q1: What is Meglumine also called?
Meglumine is also known as N-Methyl-D-glucamine or N-Methylglucamine. Its CAS number is 6284-40-8.
Q2: What is the molecular formula of Meglumine?
The molecular formula is C₇H₁₇NO₅, and its molecular weight is approximately 195.21 g/mol.
Q3: Is Meglumine soluble in water?
Yes. Meglumine is readily soluble in water. The measured solubility depends on temperature, test conditions, and the specification used.
Q4: What is Meglumine used for?
Its uses include selected pharmaceutical formulations, salt formation with acidic compounds, and the preparation of certain iodinated contrast-media salts.
Q5: What should be checked before purchasing Meglumine?
Confirm the required grade, assay, impurity limits, water content, packaging, and documentation. Pharmaceutical or other regulated applications may require specific compendial compliance and supporting quality records.
