Product Description
Meglumine, also known as N-Methyl-D-glucamine, is an organic compound derived from the glucitol structural family. Identified by CAS number 6284-40-8, it has a molecular formula of C₇H₁₇NO₅ and a molecular weight of approximately 195.22 g/mol. Its structure contains several hydroxyl groups alongside a secondary amine, giving the molecule both polyol and basic functional characteristics.
These structural features explain its value in pharmaceutical formulation development. The amine group can react with suitable acidic compounds to form salts, while the hydroxyl groups contribute to hydrogen bonding and interactions with surrounding formulation components. Meglumine is therefore used in selected formulations where salt formation, pH adjustment, or a specific excipient function is required. Its suitability must be assessed for the particular active ingredient and finished dosage form.
Meglumine is also relevant to analytical and laboratory work involving pharmaceutical ingredients and formulation behavior. The role it performs depends on the composition of the system, the target pH, solvent environment, and other ingredients. Its presence alone does not guarantee a particular solubility, stability, or bioavailability outcome; these properties need to be established for the intended formulation.
When sourcing Meglumine, buyers should distinguish the identity of the chemical from the quality grade required for its end use. Relevant specification points may include assay, water content, impurity profile, appearance, and any applicable compendial requirements. Pharmaceutical or regulated applications require documentation appropriate to the intended market and use.
Chemical Properties
| Property | Details |
|---|---|
| Product Name | Meglumine |
| CAS Number | 6284-40-8 |
| Common Chemical Name | N-Methyl-D-glucamine |
| Other Name | Methylglucamine |
| IUPAC Name | (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-pentol |
| Molecular Formula | C₇H₁₇NO₅ |
| Molecular Weight | Approximately 195.22 g/mol |
| Chemical Class | Amino sugar alcohol; polyhydroxy secondary amine |
| Functional Groups | Multiple hydroxyl groups and one secondary amine |
| Physical Form | Commonly supplied as a solid; confirm the actual product specification |
| Solubility | Water solubility should be confirmed against the supplied grade and applicable technical data |
| Main Functional Characteristics | Basic amine functionality and multiple hydrogen-bonding sites |
| Typical Formulation Roles | Salt formation, pH adjustment, and selected excipient applications |
| Storage | Follow the storage conditions specified for the supplied grade and its product documentation |
Product Applications
1. Pharmaceutical Salt Formation
Meglumine can be used to form salts with suitable acidic pharmaceutical compounds. Salt selection is compound-specific and should be evaluated for properties such as solid-state behavior, stability, and solubility.
2. pH Adjustment in Formulations
Its basic amine functionality makes Meglumine relevant to pH adjustment in selected formulation systems. The amount required and the resulting pH depend on the formulation composition and buffering environment.
3. Pharmaceutical Excipient Development
Meglumine is used in certain pharmaceutical formulations as an excipient or formulation component. Its suitability depends on the intended function, dosage form, material grade, and applicable quality requirements.
4. Formulation Compatibility Studies
Researchers may evaluate Meglumine when investigating interactions between acidic compounds, solvent systems, and other formulation ingredients. Compatibility and stability should be assessed under the intended processing and storage conditions.
5. Analytical and Chemical Research
Meglumine can serve as a defined reference material for analytical studies and research involving amino sugar alcohols, polyhydroxy compounds, and secondary amines. The selected grade should match the analytical method and required level of traceability.
FAQ
Q1: What is Meglumine CAS 6284-40-8?
Meglumine is an organic compound also known as N-Methyl-D-glucamine. Its molecular formula is C₇H₁₇NO₅, and its molecular weight is approximately 195.22 g/mol.
Q2: Is Meglumine the same as N-Methyl-D-glucamine?
Yes. N-Methyl-D-glucamine is a commonly used chemical name for Meglumine. The CAS number should be checked alongside the name to confirm identity.
Q3: What is Meglumine used for?
It is used in selected pharmaceutical formulations for salt formation, pH adjustment, and excipient-related functions. The specific role depends on the formulation and applicable product requirements.
Q4: Is Meglumine suitable for every pharmaceutical application?
No. Suitability depends on the intended use, quality grade, impurity profile, compatibility with other ingredients, and relevant regulatory requirements.
Q5: What should be checked when purchasing Meglumine?
Confirm the CAS number, assay, water content, impurity limits, physical form, and intended-use grade. For regulated applications, verify that the available quality documentation meets the requirements of the intended use and destination market.
